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    논문명(한글) Single-cell transcriptomics of bronchoalveolar lavage during PRRSV infection with different virulence
    논문명(영문) Single-cell transcriptomics of bronchoalveolar lavage during PRRSV infection with different virulence
    성과주관부서 국립축산과학원 축산생명환경부 동물바이오유전체과
    품목코드 생명공학 / 유전자 기능 및 제어 / 유전자발현조절
    학술지명 Nature Communications 주저자 임병휘,김채승
    성과년도 성과적용일 2025년03월
    Porcine reproductive and respiratory syndrome virus (PRRSV) causes significant economic losses in the global swine industry due to its high genetic diversity and different virulence levels,which complicate diseasemanagement and vaccine development. This study evaluated longitudinal changes in the immune cell composition of bronchoalveolar lavage fluid and the clinical outcomes across PRRSV strains with varying virulence, using techniques including single-cell transcriptomics. In highly virulent infection, faster viral replication results in an earlier peak lung-damage time point, marked by significant interstitial pneumonia, a significant decrease in macrophages, and an influx of lymphocytes. Viral tracking reveals less than 5% of macrophages are directly infected, and further analysis indicates bystander cell death, likely regulated by exosomalmicroRNAs as a significant factor. In contrast, the peak intermediate infection shows a delayed lung-damage time point with fewer cell population modifications. Furthermore, anti-inflammatory M2-like macrophages (SPP1-CXCL14high) are identified and their counts increase during the peak lung-damage time point, likely contributing to local defense and lung recovery, which is not observed in high virulent infection. These findings provide a comprehensive description of the immune cellular landscape and differential PRRSV virulence mechanisms, which will help build new hypotheses to understand PRRSV pathogenesis and other respiratory infections.
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